Mono Sclerosis :: Stop MS in its tracks before it becomes Multiple

Explanation for HDOT

The point of the greatest activity of accumulation of fluid in tissue space that characterises lesions typical of MS, inevitably increases the spreading distance for oxygen, and provides a sound explanation for increasing the oxygen concentration of the blood under hyperbaric conditions.

This increases the rate for transfer into the tissue. The calibre of the cerebral blood vessels is related to the oxygen tension of the blood that passes through it, and the blood-brain barrier is oxygen dependent.

The effectiveness of HDOT in the reduction of global cerebral accumulation of fluid in tissue space has been demonstrated by direct measurement in man (Sukoff & Ragatz 1982) and Rockswold et al (1992) have shown that HDOT reduces the mortality of severe head injury by 50.

In 1986 Neubauer and Kagan showed the effect of HDOT on the accumulation of fluid in tissue space associated with MS. They found that one or more lesions shown on MRI disappeared in 11 of 35 patients (31.4) after 1 hour of treatment, which suggests that it is the resolution of focal edema that accounts for the improvement.

When natural remission occurs in MS, the critical factor in barrier and tissue repair in the Central Nervous System is the availability of tissue oxygen. The driving force to increase the delivery to the tissue is the blood oxygen tension. A mild disturbance of the barrier may simply increase the water content of the nervous tissue, but more severe failure is associated with the pouring out of blood constituents, including proteins, into the extracellular space and thence to neural tissue.

This degree of barrier failure primarily causes damage to myelin. The most severe form of blood-brain barrier failure is associated with blood vessels around the brain pouring out red blood cells and tissue death caused by loss of blood supply.

Using the animal model experimental allergic encephalomyelitis (EAE), Warren et al (1978) showed that daily HDOT completely suppresses the development of paralytic disease in rodents for at least 34 days. Prockop and Grasso (1978) also found amelioration of EAE in guinea pigs.

Hansbrough et al (1980) demonstrated that HDOT is immunosuppressive in mice. Abboter al (1994) showed that the inflammation produced by the tuberculin reaction in man can be associated with a developing tissue deficient of oxygen that results from accumulation of fliud in tissue space limiting the rate of oxygen flux at a time when the area is being invaded by highly metabolically active cells.

High Dosage Oxygen & Best Bet Diet Combo Treatment

Throughout these webpages reference is made to Blood Brain Barrier (BBB) breach in the description of the cause of MS and the effectiveness of the Best Bet Diet in tackling it. High Dosage Oxygen Treatment tackles the same problem (BBB breach) and is very effective on its own. Combining both forms of treatment can be of greater benefit. Both forms of treatment compliment each other and boosts the effectiveness required to combat Multiple Sclerosis. That is not to say that each treatment as a stand alone form of treating MS is less effective, it just gives you that bit extra that we all need.

No reference is made in Tim Stout's or Ashton Embry's excellent articles to the use or value of HDOT in tackling BBB breach, nor can I find any reference to Best Bet Diet and supplements in any articles about HDOT. A program of combined treatment should be considered for any trials to have the maximum effect to combat Multiple Sclerosis. Until then, please consider trying it out for yourselves. It is your body, your choice.

This combination of treatment could also be beneficial to other neurological illness as Blood Brain Barrier breach/compromise has also been found. The Blood Brain Barrier encapsulates the whole brain, the location or site of the BBB breach could determine the effect on the brain and the consequent illness that the person then suffers from. In the case of Multiple Sclerosis, that would explain why no two people are alike in the way that they are affected by MS. The BBB breach location and severity could well pre-determine the onset and progression of the disease.

Once the BBB has been breached/compromised in one location/site, then that is where the entrance to the sensitive tissue remains to be attacked repeatedly. The foundation stone of all this is poor/western diet causing leaky gut syndrome which in turn causes BBB breach, which then results in a neurological illness of some description.

Based on the above hypothesis, the Best Bet Diet and High Dosage Oxygen Therapy could be used to treat a wide range of illnesses. To strengthen the BBB could have the effect of slowing down the progression of Multiple Sclerosis and to do this you will need to challenge what caused the breach in the first place..your diet! Use HDOT as an extra building block to help heal the damage caused and you will have a powerful combined force to combat your illness.

Oxygen to reduce inflammation.
During an MS attack there is typically substantial inflammation at the location where the lymphocytes are destroying the myelin. There is some indication that myelin could have a tendency to reform after the attack were it not for the scar tissue left behind. There is also indication that the scar tissue is formed because of the inflammation. Hence, if one could reduce the level of inflammation during an attack, it may be possible to reduce the long-range impact of the attack. Much about this is speculative and not well documented.

Several studies have been made concerning the effectiveness of drugs that typically reduce inflammation, but their effectiveness has not been encouraging. That does not necessarily mean that the concept is invalid, it could merely be that the particular drugs tested happened to be ineffective at an MS site, whereas a different one might yet prove to be effective.

Oxygen is the most effective anti-inflammatory available.